doi: 10.23937/2378-3656/1410150 Summary Keywords euglycemic diabetic ketoacidosis (euDKA), SGLT-2 inhibitor, GLP-1 receptor agonist, type 2 diabetes mellitus, adverse drug reaction Citation Gandecka-Pempera A, Naskrt D, Adamska A and Zozuliska-Zikiewicz D (2025) Severe euglycemic ketoacidosis following combined therapy with GLP-1 receptor agonist and SGLT-2 inhibitor, refractory to standard treatment: a case report
GLP-1 medications commonly referenced in reported side effect claims include Ozempic, Wegovy, Mounjaro, Rybelsus, Trulicity, and other GLP-1 receptor agonists prescribed for diabetes or weight loss
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However, the limitation of tirzepatide is that it does not directly engage the glucagon receptor , which plays a crucial role in fat metabolism, hepatic energy expenditure, and thermogenesis